Matrix metalloproteinase interactions with collagen and elastin

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Matrix metalloproteinase interactions with collagen and elastin

Most abundant in the extracellular matrix are collagens, joined by elastin that confers elastic recoil to the lung, aorta, and skin. These fibrils are highly resistant to proteolysis but can succumb to a minority of the matrix metalloproteinases (MMPs). Considerable inroads to understanding how such MMPs move to the susceptible sites in collagen and then unwind the triple helix of collagen mono...

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Neck Contracture Release With Matriderm Collagen/Elastin Dermal Matrix

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Cleavage of the fibrillar collagens occurs during physiological conditions, as well as pathological conditions. The resistance of the fibrillar collagens to degradation is due to their rigid and compact structures. There are only a limited number of proteinases that have the capability to initiate the cleavage of the fibrillar collagens. These include some of the matrix metalloproteinases (MMPs...

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Arterial extracellular matrix: a mechanobiological study of the contributions and interactions of elastin and collagen.

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Collagen and elastin fibres.

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ژورنال

عنوان ژورنال: Matrix Biology

سال: 2015

ISSN: 0945-053X

DOI: 10.1016/j.matbio.2015.01.005